Reconstructing phosphorylation signalling networks from quantitative phosphoproteomic data
نویسندگان
چکیده
منابع مشابه
Directional and quantitative phosphorylation networks.
Directionality in protein signalling networks is due to modulated protein-protein interactions and is fundamental for proper signal progression and response to external and internal cues. This property is in part enabled by linear motifs embedding post-translational modification sites. These serve as recognition sites, guiding phosphorylation by kinases and subsequent binding of modular domains...
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ژورنال
عنوان ژورنال: Essays in Biochemistry
سال: 2018
ISSN: 0071-1365,1744-1358
DOI: 10.1042/ebc20180019